Latest Publications
2026
Linna E, Rossi HR, Klarskov N, Svenningsen R, Mikkola T, Kuismanen K, Jónsdóttir K, Cheema R, Piltonen T, Olsen IP. A Nordic perspective on female stress urinary incontinence care: Lessons for shared clinical practice. Acta Obstet Gynecol Scand. 2026 May 19. doi: 10.1111/aogs.70265. Epub ahead of print. PMID: 42156336.
Teede HJ, Khomami MB, Morman R, Laven JSE, Joham AE, Costello MF, Patil M, Rees DA, Berry L, Cree MG, Zhao H, Norman RJ, Dokras A, Piltonen T; Global Name Change Consortium. Polyendocrine metabolic ovarian syndrome, the new name for polycystic ovary syndrome: a multistep global consensus process. Lancet. 2026 May 12:S0140-6736(26)00717-8. doi: 10.1016/S0140-6736(26)00717-8. Epub ahead of print. PMID: 42119588.
Piltonen TT, Kuusiniemi E, Teede H; WENDY Research Group study group. Ovarian Cysts in Polycystic Ovary Syndrome. JAMA Intern Med. 2026 May 11:e261370. doi: 10.1001/jamainternmed.2026.1370. Epub ahead of print. PMID: 42113530; PMCID: PMC13162137.
Joensuu L, Lukander V, Herranen P, Tynkkynen NP, Kujala U, Lopéz-Bueno R, Nordeidet AN, Klevjer M, Øvretveit K, Wisløff U, Bye A, Ekelund U, Ollikainen M; FinnGen; Sillanpää E. Evaluation of Genetics in the Association Between Cardiorespiratory Fitness and Health: Insights from a Genome-Wide Polygenic Score for Cardiorespiratory Fitness in the FinnGen and HUNT cohorts. Scand J Med Sci Sports. 2026 May;36(5):e70291. doi: 10.1111/sms.70291. PMID: 42087449; PMCID: PMC13145328.
Moolhuijsen LME, Zhu J, Mullin BH, Pujol-Gualdo N, Actkins KV, Mack JA, Rao H, Trivedi B, Kentistou KA, Zhao Y, Westergaard D, Tyrmi JS, Thorleifsson G, Zhang Y, Wittemans L, DeVries A, Brewer K, Sisk R, Danning R, Preuss MH, Jones MR, Ruth KS, Andersen M, Azziz R, Banasik K, Boehnke M, Broer L, Brunak S, Chan YM, Chasman DI, Daly M, Ehrmann DA, Fauser BC, Fritsche LG, Hayes MG, He C, Huang H, Kowalska I, Kraft P, Legro RS, Lin N, Loos RJ, Louwers YV, Magi R, McCarthy MI, Morin-Papunen L, Morrison JV, Morton C, Nadkarni GN, Neale BM, Nielsen HS, Nyegaard M, Ostrowski SR, Pedersen OBV, Sørensen E, Mikkelsen C, Erikstrup C, Kaspersen KA, Bruun MT, Aagaard B, Ullum H, Obermayer-Pietsch B, Palotie A, Reeve MP, Salumets A, Saxena R, Spector TD, Stuckey BGA, Thorsteinsdottir U, Uitterlinden AG, Urbanek M, Zöllner S; Genes and Health Research Team; DBDS Genomic Consortium; 23andMe Research Team; van Heel DA, Hirschhorn JN, Stefansson K, Perry JRB, Styrkarsdottir U, Wilson SG, Piltonen T, Laisk T, Jarvelin MR, Burns K, Justice AE, Laivuori H, Ong KK, Goodarzi MO, Davis LK, Dunaif A, Lindgren CM, Laven JSE, Franks S, Visser JA, Welt CK, Karaderi T, Day FR. Genomic analyses implicate hormonal and metabolic dysregulation in polycystic ovary syndrome. Nat Genet. 2026 May;58(5):1040-1050. doi: 10.1038/s41588-026-02543-9. Epub 2026 Apr 23. PMID: 42026183; PMCID: PMC13175888.
Telkkälä A, Jokelainen J, Piltonen T, Huilaja L, Sinikumpu SP. Body Image Satisfaction among Patients with Female Acne. Acta Derm Venereol. 2026 Apr 9;106:0484. doi: 10.2340/actadv.v106.adv-2026-0484. PMID: 41954308; PMCID: PMC13063222.
Lavi J, Savukoski S, Hurskainen E, Ollila MM, Morin-Papunen L, Niinimäki M, Piltonen TT. Women with PCOS have a later menopausal transition and a lower prevalence of menopausal symptoms at age 46: A population-based birth cohort study. Acta Obstet Gynecol Scand. 2026 May;105(5):836-846. doi: 10.1111/aogs.70198. Epub 2026 Apr 8. PMID: 41949217; PMCID: PMC13125374.
Salo V, Määttä J, Takala J, Heikkilä A; FinnGen; Reimann E, Mägi R; Estonian Biobank Research Team; Reis K, Elhanas AG, Reigo A, Palta P, Esko T, Leinonen V, Karppinen J, Sliz E, Kettunen J. Genetic architecture of lumbar spinal stenosis. Nat Commun. 2026 Apr 6. doi: 10.1038/s41467-026-70935-w. Epub ahead of print. PMID: 41942452.
Salmi VM, Karppinen JE, Piltonen TT, Kyröläinen H, Hulmi JJ, Ihalainen JK, Mikkonen RS. Correction: Androgen levels of premenopausal females are not observably associated with body composition and physical performance, but may interact with hormonal contraceptive use. Eur J Appl Physiol. 2026 Apr;126(4):1953. doi: 10.1007/s00421-025-06043-2. Erratum for: Eur J Appl Physiol. 2026 Apr;126(4):1937-1951. doi: 10.1007/s00421-025-05993-x. PMID: 41915061; PMCID: PMC13172004.
Toivonen J, Clancy J; FinnGen; Åberg F, Ritari J, Arvas M. Quantifying risk modifiers of hereditary hemochromatosis using genomic and electronic health record data. JHEP Rep. 2026 Apr;8(4):101774. doi: 10.1016/j.jhepr.2026.101774. Epub 2026 Feb 6. PMID: 41861673; PMCID: PMC13019596.
Kuuluvainen E, Kaila-Vanhatalo M, Nordström T, Piltonen TT, Pinola P. Health disparities among LGBTQ+ adults aged 33-35 in northern Finland: findings from the NFBC1986 cohort. J Sex Med. 2026 Jan 7;23(2):qdaf366. doi: 10.1093/jsxmed/qdaf366. PMID: 41521673.
Glintborg D, Ollila MM, Koskenkari N, Møller JK, Calla D, Gyllenberg F, Rubin KH, Pesonen P, Andersen MS, Sundström-Poromaa I, Piltonen T. Increased prospective cardiovascular disease risk in 127 517 Nordic women with polycystic ovary syndrome: a national cohort study. Eur J Endocrinol. 2026 Jan 6;194(1):58-68. doi: 10.1093/ejendo/lvaf266. PMID: 41439462.
2025
Saklatvala JR, Lessard S, Teder-Laving M, Thomas LF, Ramessur R, Zierer J, Åsvold BO, Barton A, Baudry D, Bowes J, Brumpton B, Bruno S, Chandran V, Chatelain C, de Rinaldis E, Elder JT, Ellinghaus D, Foerster J, Franke A, Gladman DD, Gulliver W, Hüffmeier U, Huilaja L, Hveem K, Khader S, Kingo K, Klinger K, Kolbinger F, Kõks S, Liao W, Nair RP, Nititham J, Rahman P, Reis A, Sagoo MK, Stuart PE, Tasanen K, Traks T, Tsoi LC, Uebe S, Watts K; BSTOP study group; Barker JN, Mahil SK, Langan SM; FinnGen; Estonian Biobank research team; Brown SJ, Løset M, Paternoster L, Dand N, Smith CH, Simpson MA. Genetic liability to psoriasis predicts severe disease outcomes. Genome Med. 2025 Dec 17;18(1):14. doi: 10.1186/s13073-025-01561-2. PMID: 41408349; PMCID: PMC12857016.
Telkkälä A, Jokelainen J, Piltonen T, Huilaja L, Sinikumpu SP. The Prevalence and Characteristics of Adult Female Acne: A Cross-sectional Population-based Study. Acta Derm Venereol 2025 Oct 29:105:adv44151.doi: 10.2340/actadv.v105.44151.
Salmi VM, Karppinen JE, Piltonen TT, Kyröläinen H, Hulmi JJ, Ihalainen JK, Mikkonen RS. Androgen levels of premenopausal females are not observably associated with body composition and physical performance, but may interact with hormonal contraceptive use. Eur J Appl Physiol. 2025 Sep 22. doi: 10.1007/s00421-025-05993-x. Online ahead of print. PMID: 40976810
Vuontisjärvi S, Rossi HR, Nordström T, Karjula S, Terho A, Morin-Papunen L, Koivurova S, Piltonen TT. Women with endometriosis have decreased health-related quality of life until late fertile age: a population-based cohort analysis at ages 31 and 46 years. Hum Reprod. 2025 Oct 1;40(10):1909-1918. doi: 10.1093/humrep/deaf154. PMID: 40795399
Nynäs E, Sulkava S, Nurmi AK, Suvanto M, Aittomäki K; FinnGen; Nevanlinna H. Recessive FANCM cancer syndrome with high cancer risks, chemotherapy toxicity, chromosome fragility, and gonadal failure. Genet Med. 2025 Jul 7;27(10):101521. doi: 10.1016/j.gim.2025.101521. Epub ahead of print. PMID: 40642874
Mak JKL, Qin C, Krüger M, Kuukka A; FinnGen; Hägg S, Lin J, Jylhävä J. Large-scale genome-wide analyses with proteomics integration reveal novel loci and biological insights into frailty. Nat Aging. 2025 Aug;5(8):1589-1600. doi: 10.1038/s43587-025-00925-y. Epub 2025 Aug 5. PMID: 40764432
Teede HJ, Moran LJ, Morman R, Gibson M, Dokras A, Berry L, Laven JSE, Joham A, Piltonen TT, Costello MF, Norman RJ, Bahri Khomami M. Polycystic ovary syndrome perspectives from patients and health professionals on clinical features, current name, and renaming: a longitudinal international online survey. EClinicalMedicine. 2025 May 28;84:103287. doi: 10.1016/j.eclinm.2025.103287. eCollection 2025 Jun. PMID: 40687737
Salminen A, Hyvärinen K, Ritari J, Caetano A, Kambur O, Mäntylä P, Yilmaz M, Sinisalo J; FinnGen; Perola M, Havulinna A, Nibali L, Gürsoy UK, Pussinen PJ. Genetic Loci Associated With Periodontitis: The FinnGen Study Based on National Health Registers. J Clin Periodontol. 2025 Sep;52(9):1263-1275. doi: 10.1111/jcpe.14193. Epub 2025 Jul 19. PMID: 40682483
Luyckx L, Wei M, Saarela U, Myllykangas M, Kinnunen J, Arffman R, Lie Fong S, Vriens J, Vankelecom H, Piltonen TT. PCOS endometrium-derived epithelial organoids as a novel model to study endometrial dysfunction. Hum Reprod. 2025 Jun 11:deaf113. doi: 10.1093/humrep/deaf113. Epub ahead of print. PMID: 40499150.
Garay OU, Olziersky AM, Laven J, Mawson R, Piltonen T, Franks S, Sillman J. Economic impact of the Elecsys anti-Müllerian hormone Plus immunoassay for anti-Müllerian hormone testing as part of polycystic ovary syndrome assessment in the United Kingdom PLoS One. 2025 Jun 17;20(6):e0326162. doi: 10.1371/journal.pone.0326162. eCollection 2025. PMID: 40526694
Eghtedarian R, Tervi AM, Jones SE; FinnGen; Partinen M, Viippola E, Ollila. Narcolepsy as a potential risk factor for Schizophrenia. Transl Psychiatry.2025 Feb 17;15(1):55. doi: 10.1038/s41398-025-03259-w. PMID: 39962082; PMCID: PMC11832773.
Virtanen N, Pesonen E, Saarela U, Hurskainen E, Arffman RK, Koivunen P, Piltonen T. Association of hemoglobin levels with metabolic traits in women with PCOS. Acta Obstet Gynecol Scand. 2025 Feb;104(2):357-367. doi: 10.1111/aogs.15047. Epub 2024 Dec 30.
Nurkkala M, Salo H, Piltonen T, Sova H, Rossi HR. Efficacy of 100-U Onabotulinumtoxin A Treatment in Female Idiopathic Overactive Bladder-A Prospective Follow-Up Study. Int Urogynecol J. 2025 Mar;36(3):685-693. doi: 10.1007/s00192-025-06047-8. Epub 2025 Jan 31. PMID: 39888383; PMCID: PMC12003622.
Piltonen TT, Kinnunen J, Komsi E, Kangasniemi MH, Luiro K, Rajecki M, Jokelainen J, Kiviniemi E, Allegranza D, Hund M, Olziersky AM, Logan CA, Buck K, Savukoski SM, Arffman RK. Prospective validation of anti-Müllerian hormone cutoff to determine polycystic ovarian morphology: HARMONIA study Fertil Steril. 2025 Sep;124(3):543-552. doi: 10.1016/j.fertnstert.2025.05.147. Epub 2025 May 19. PMID: 40398715
Han TS, Hannemann A, Arffman R, Friedrich N, Ittermann T, Wilkening R, Piltonen T, Fry CH, Crujeiras AB, Casanueva FF. The relationship between hypoprolactinemia and cardiometabolic health in women. Eur J Endocrinol. 2025 Apr 30;192(5):662-670. doi: 10.1093/ejendo/lvaf101. PMID: 40354121
Luyckx L, Myllykangas M, Saarela U, Virtanen N, Hurskainen E, Savolainen A, Ollikainen N, Norlén AK, Ohlsson C, Poutanen M, Velde GV, Arffman RK, Prunskaite-Hyyryläinen R, Vriens J, Piltonen TT. Prenatally androgenized PCOS mice have ovary-independent uterine dysfunction and placental inflammation aggravated by high-fat diet. Sci Adv. 2025 May 9;11(19):eadu3699. doi: 10.1126/sciadv.adu3699. Epub 2025 May 9.
Morin-Papunen L, Pelkonen S, Piltonen T. Polycystic ovary syndrome: What to say when asked about the chance of pregnancy. Acta Obstet Gynecol Scand. 2025 Jul;104(7):1228-1230. doi: 10.1111/aogs.15149. Epub 2025 May 7. PMID: 40329712
Martiskainen H, Willman RM, Harju P, Heikkinen S, Heiskanen M, Müller SA, Sinisalo R, Takalo M, Mäkinen P, Kuulasmaa T, Pekkala V, Galván Del Rey A, Juopperi SP, Jeskanen H, Kervinen I, Saastamoinen K; FinnGen; Niiranen M, Heikkinen SV, Kurki MI, Marttila J, Mäkinen PI, Rostalski H, Hietanen T, Ngandu T, Lehtisalo J, Bellenguez C, Lambert JC, Haass C, Rinne J, Hakumäki J, Rauramaa T, Krüger J, Soininen H, Haapasalo A, Lichtenthaler SF, Leinonen V, Solje E, Hiltunen M. Monoallelic TYROBP deletion is a novel risk factor for Alzheimer’s disease. Mol Neurodegener. 2025 Apr 29;20(1):50. doi: 10.1186/s13024-025-00830-3. PMID: 40301889
Haapakangas SM, Koskenkari NVS, Hurskainen EL, Arffman RK, Ollila MM, Piltonen TT. Neck circumference as a metabolic health marker among women with polycystic ovary syndrome (PCOS): a systematic review and meta-analysis. Int J Obes (Lond). 2025 Apr 21. doi: 10.1038/s41366-025-01753-1.
Tuorila K, Pesonen E, Ollila MM, Hurskainen E, Nurkkala M, Korpelainen R, Niemelä M, Morin-Papunen L, Piltonen TT. Hyperandrogenaemia, PCOS, and Physical Fitness in Women – A Northern Finland Birth Cohort Study. Eur J Endocrinol. 2025 Apr 16:lvaf080. doi: 10.1093/ejendo/lvaf080.
Hoeger KM & Piltonen TT. The Environment and Reproduction. Semin Reprod Med. 2024 Dec;42(4):249-250. doi: 10.1055/s-0044-1801397. Epub 2025 Mar 10.
Lee S, Aasmets O, Arffman RK, Laru J, Rossi HR, Salumets A, Piltonen TT, Org E. The reproductive tract microbiome in women with polycystic ovary syndrome and across different menstrual cycle phases. Hum Reprod. 2025 Mar 1;40(3):518-528. doi: 10.1093/humrep/deae270. PMID: 39792897.
Pesonen E, Nurkkala M, Ollila MM, Hurskainen E, Morin-Papunen LC, Jämsä T, Korpelainen R, Niemelä M, Piltonen TT. Women with polycystic ovary syndrome are at risk of emotional and uncontrolled eating at midlife: a population-based cohort study. Fertil Steril. 2025 Mar;123(3):383-393.doi: 10.1016/j.fertnstert.2024.09.042. Epub 2024 Sep 29.
Ollila MM, Hautakoski A, Arffman M, Morin-Papunen L, Koivikko M, Ebeling T, Sund R, Piltonen T. Diabetic complications in women with type 2 diabetes and polycystic ovary syndrome. Eur J Endocrinol. 2025 Mar 3;192(3):202-209. doi: 10.1093/ejendo/lvaf026.